Global shortcuts (valid everywhere in RemotePLE):

F1: Open the help, context-sensitive to the current area.
F9: Open the event scheduler.
F10: Open the settings.
F11: Open the server profile window; inside the cue point editor the help instead.
F12: Open the release notes.

Ctrl+T: Open or close the cue point editor.
Ctrl+F: Open or close the song search.
Ctrl+P: Play or pause; if nothing is running, the selected track is played.
Ctrl+S: Save the current playlist; in the Preset tab the preset, in the cue point editor the cue points.
Ctrl+L: Start or stop the live stream.
Ctrl+M: Switch the speech guide on or off.
Ctrl+R: Start or stop the recording; switches to the VoiceTrack tab in doing so.
Ctrl+E: Open the selected text file in the internal editor.
Ctrl+V: Upload a file from the clipboard (only if an upload directory is set up).
Ctrl+W: Open the song requests.
Ctrl+N: Open the voice messages (only when a message folder is configured).
Ctrl+A: Select all entries of the current list.
Ctrl+B: Trim the voice track (only in the cue point editor).
Ctrl+Z: Reset the cue point (only in the cue point editor).

In the lists:
Delete: Delete the selected entries.
Backspace: In the directory lists one level up. In the root directory it is announced that there is no level above.

Tab switching (left side):
Shift+F1: Focus on Playlist.
Shift+F2: Focus on FTP.
Shift+F3: Focus on Preset.
Shift+F4: Focus on OnAir.

Tab switching (right side - sources):
Shift+F5: Focus on Song.
Shift+F6: Focus on VoiceTrack.
Shift+F7: Focus on Jingle.
Shift+F8: Focus on Drop.
Shift+F9: Focus on Opener.
Shift+F10: Focus on Promo.
Shift+F11: Focus on Contributions.
Shift+F12: Focus on RadioBOSS.

Escape: Cancel the search or close the current dialog window.
